Transcriptional Repression by p53 through Direct Binding to a Novel DNA Element
نویسندگان
چکیده
منابع مشابه
E2F7, a novel target, is up-regulated by p53 and mediates DNA damage-dependent transcriptional repression.
The p53 tumor suppressor protein is a transcription factor that exerts its effects on the cell cycle via regulation of gene expression. Although the mechanism of p53-dependent transcriptional activation has been well-studied, the molecular basis for p53-mediated repression has been elusive. The E2F family of transcription factors has been implicated in regulation of cell cycle-related genes, wi...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2001
ISSN: 0021-9258
DOI: 10.1074/jbc.c100121200